Biochemical Studies of the Nucleoside Analogue, Formycin

Biochemical studies of the nucleoside analogue, formycin.

The absorption and fluorescence properties of formycin provide a useful tool in the analysis of enzyme-substrate interactions; we have therefore studied selected biochemical properties of formycin nucleotides. Formycin and its derivatives effectively substitute for the corresponding adenosine substrates in a wide variety of enzyme reactions. These include enzymes of nucleotide metabolism, RNA p...

Biochemical Effects of Formycin, an Adenosine Analog1

The effects of formycin (7-amino-3-(/3-D-ribofuranosyl)pyrazolo(4,3-d)-pyrimidine), an adenosine analog, on purine metabolism in Ehrlich ascites tumor cells were studied. Purine biosynthesis de novo was blocked by formycin through inhibition of phosphoribosylpyrophosphate synthesis, and this did not occur in cells which did not phosphorylate formycin. This analog had no significant effect on ad...

Effect of Purine Nucleoside Analogue-Acyclovir on The Sperm Parameters and Testosterone Production in Rats

analysis of reading comprehension needs of the students of paramedical studies: the case of the students of health information management (him)

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Biochemical effects of formycin B on Xanthomonas oryzae.

Formycin B, an inosine analogue, inhibits the incorporation of radioactive adenosine, uridine and thymidine, but none of formic acid, orotic acid and inorganic phosphoric acid into the cellular nucleic acid of Xanthomonas oryzae. The biochemical effects are readily reversed when formycin B is removed. Cell-free extract from the organism is entirely insensitive to formycin B in respect to phosph...